Membrane Anchored VEGF Cell
CBP74156
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| I. Background | |
| The outline of the regulation of VEGF receptor (VEGFR) signaling by membrane traffic is similar to that of the epidermal growth factor receptor (EGFR), a prototype of the intertwining between membrane traffic and signaling. There are, however, unique features in VEGFR signaling that are conferred in part by the involvement of the co-receptor neuropilin (Nrp). Nrp1 and VEGFR2 are integrated into membrane traffic through the adaptor protein synectin, which recruits myosin VI, a molecular motor that drives inward trafficking . | |
| II. Introduction | |
| Expressed gene: | Membrane Anchored VEGF |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+5ug/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| III. Representative Data | |
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Figure 1. Membrane Anchored VEGF Cell flow cytometry data. |
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Figure 2. Dose response of Bevacizumab in ADCC Bioassay Effector Cell (High Affinity/NFAT-Jurkat cells) With Membrane Anchored VEGF Cells (Clone 9). |
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