c-Kit W557_K558del/BaF3
CBP73233
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產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫(kù)
| I. Introduction | |
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Cell Line Name： |
c-Kit W557_K558del/BaF3 |
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Host Cell: |
Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
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Application: |
Anti-proliferation assay and PD assay |
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Freeze Medium: |
90% FBS+10% DMSO |
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Complete Culture Medium: |
RPMI-1640+10%FBS |
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Mycoplasma Status: |
Negative |
| Ⅱ. Background | |
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KIT W557del results in the deletion of an amino acid in the juxtamembrane domain (exon 11) of the Kit protein at amino acids 557 (PMID: 12918066). W557del has not been characterized, however similar Kit exon 11 deletions are activating (PMID: 9438854, PMID: 9797363), and therefore, is predicted to lead to a gain of Kit protein function . |
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| III. Representative Data | |
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1. WB of c-Kit W557_K558del/BaF3
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2.Sanger of c-Kit W557_K558del/BaF3
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3. Anti-proliferation assay
Figure 3. CTG Proliferation Assay of BaF3 c-KIT W557_ K558del (C2). |
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