CD74-ROS1/BaF3
CBP73331
| I. Introduction | |
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Cell Line Name： |
CD74-ROS1/BaF3 |
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Host Cell: |
Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
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Freeze Medium: |
90% FBS+10% DMSO |
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Complete Culture Medium: |
RPMI-1640+10%FBS |
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Mycoplasma Status: |
Negative |
| II. Background | |
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CD74, CD74 molecule, encodes for a type II integral membrane glycoprotein that acts as an MHC class II chaperone and plays a role in the signal transduction of pathways related to cell survival, proliferation (PMID: 16484589, PMID: 27058619), and the immune system (PMID: 30191677). Overexpression of Cd74 has been observed in gastrointestinal cancer (PMID: 21228923) and hematological cancers (PMID: 30191677), and CD74-ROS1 and CD74-NRG1 fusions have been identified in lung cancer (PMID: 22215748, PMID: 31027745, PMID: 29169524). |
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| III. Representative Data | |
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1. Sanger of CD74-ROS1/BaF3
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2. Anti-proliferation assay |
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Figure 2. CTG Proliferation Assay of BaF3 CD74-ROS1 Cells (C1) |
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