LOVO（人結腸癌腫瘤細胞）
CBP60032
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| I. General information | |
| Synonyms: | LOVO |
| Background: | LoVo was initiated in 1971 from a fragment of a metastatic tumor nodule in the left supraclavicular region of a 56-year-old Caucasian male patient with a histologically proven diagnosis of adenocarcinoma of the colon. |
| Species: | Homo sapiens, human |
| Tissue: | colon; derived from metastatic site: left supraclavicular region |
| Disease: | Dukes' type C, grade IV, colorectal adenocarcinoma |
| Gender: | male,56 years |
| Morphology: | epithelial |
| Growth Mode: | adherent |
| DNA Profile: | Amelogenin: XY CSF1PO: 11,13,14 D13S317: 8, 11 D16S539: 9, 12 D5S818: 11, 12, 13 D7S820: 9.3,10, 11 THO1: 9.3 TPOX: 8,9 vWA: 17,18 Cobioer’s Cell Line Authentication Service |
| Culture Medium: |
DMEM+10%FBS We strongly suggest to purchase the complete medium from Cobioer. |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Antigen Expression: | HLA A11, B15, B17, Cw1, Cw3; blood type B |
| Oncogene: | myc +; myb + ; ras +; fos +; p53 +; sis -; abl -; ros -; src - |
| Genes Expressed: | carcinoembryonic antigen (CEA) 908 ng/10 6 cells/10 days. The cells are negative for expression of CSAp (CSAp-) and colon antigen 3. |
| Cellular Products: | carcinoembryonic antigen (CEA) 908 ng/10 exp6 cells/10 days |
| Tumor Formation: | Yes, in nude mice,(Tumors developed within 21 days at 100% frequency (5/5) in nude mice inoculated subcutaneously with 10(7) cells) |
| Comments: | The cells are negative for expression of CSAp (CSAp-) and colon antigen 3.The line is positive for expression of c-myc, K-ras, H-ras, N-ras, Myb, sis and fos oncogenes. N-myc and sis oncogene expression were not detected. Tumor specific nuclear matrix proteins CC-3 and CC-4 are expressed. For more information, please contact Cobioer (4008-750-250). |
